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Hydrochloric Acid → 7-methyl-8H-1,8-naphthyridin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 5373687 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 7-methyl-8H-1,8-naphthyridin-4-one | HCID 178422956 | 83% |
反応手順
A solution of the product from Example 7b (1.30 g, 5.59 mmol) and NaOH (233 mg, 5.82 mmol) in 20 mL of water was heated in a sealed metal reactor at 180° C. for 16 h. Cooled to room temperature and adjusted to pH 6 with 1N HCl. The resulting precipitates was filtered and dried under vacuum giving the title compound as a black solid (743 mg, 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08236950B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-c385763234854722b8dd8f16ff9d8b7d |
| 出典メモ | uspto-grants-2012_08 |