関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 反応物 | 6-Ethylpyridin-2-amine | HCID 89021 | — |
| 生成物 | Diethyl 2-((6-ethylpyridin-2-ylamino)methylene)malonate | HCID 12354398 | — |
反応手順
The crude product from Example 8b was combined with 2-ethoxymethylene-malonic acid diethyl ester (6.6 mL, 0.032 mol) and the mixture heated under a N2 atmosphere in an oil bath at 100° C. for 2 h. Purified by flash chromatography on silica gel eluting with EtOAc/hexane giving the title compound (7.16 g, 98%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08236950B2 |
|---|
| 出典データセット | uspto-grants-2012_08 |
|---|
| ORD ID | ord-eb849b1d0bbe4df2b73112607cc62a02 |
|---|
| 出典メモ | uspto-grants-2012_08 |
|---|
