Ammonia → HCID 45122229、化合物

HRID 883864ノート

反応式

HRID 883864 の反応式
Br[C:2]1[N:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH3:13]>C(O)C>[NH2:13][C:2]1[N:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

参加物

4

反応物 2

HCID 222AmmoniaHCID 84689561HCID 84689561、化合物

生成物 1

HCID 45122229HCID 45122229、化合物収率 93%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of the product of Example 12C (21 g, 0.093 mol) and liquid ammonia (250 mL) in 500 mL of ethanol were reacted in a sealed high-pressure vessel at 130° C. for 20 hours. The reaction mixture was concentrated under vacuum and the residue ground to a fine powder then washed with water (2×50 mL) and dried in a vacuum oven for 24 hours to provide the title compound as a beige solid (14 g, 93%).

後処理

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. washthe residue ground to a fine powder then washed with water (2×50 mL)
  3. customdried in a vacuum oven for 24 hours

出典と根拠

ORDレコード
ord-6146cdbb886e498b911eb268ca812085
出典データセット
uspto-grants-2012_08
特許番号
US08236950B2

反応ノート

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