N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine → 4-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol

HRID 883931ノート

反応式

HRID 883931 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([OH:16])[CH:5]=[CH:6][C:7]=1[S:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1.C([C:19]1[C:20]([N:25]=[CH:26][N:27]([CH3:29])C)=[N:21][CH:22]=[CH:23][CH:24]=1)#N.NC1C=C(OCC2C=CC=C(F)C=2)C=CC=1SC1C=CC(O)=CC=1>>[OH:15][C:12]1[CH:13]=[CH:14][C:9]([S:8][C:7]2[CH:6]=[CH:5][C:4]([OH:16])=[CH:3][C:2]=2[NH:1][C:29]2[C:19]3[CH:24]=[CH:23][CH:22]=[N:21][C:20]=3[N:25]=[CH:26][N:27]=2)=[CH:10][CH:11]=1

参加物

4

反応物 3

HCID 66808319N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidineHCID 668086774-[2-Amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenolHCID 670403013-Amino-4-(4-hydroxy-phenylsulfanyl)-phenol2 回

生成物 1

HCID 670407844-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol収率 35.4%

実験手順

The product of Example 48B (380 mg, 1.63 mmol) was reacted with the product of Example 15A (284 mg, 1.63 mmol) using the procedure of Example 15E substituting the product of Example 48B for the product of Example 15D to provide a solid which was triturated with methanol to provide the title compound (209 mg, 35%).

後処理

  1. customto provide a solid which
  2. customwas triturated with methanol

出典と根拠

ORDレコード
ord-48658e87e4e14f8a8d5f6ec4b419f02c
出典データセット
uspto-grants-2012_08
特許番号
US08236950B2

反応ノート

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