Potassium Carbonate → 1-Nitro-3-(3-bromo-phenoxymethyl)-benzene

HRID 883970

反応式

HRID 883970 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Cl)([O-:3])=[O:2].[Br:12][C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N+:1]([C:4]1[CH:11]=[CH:10][CH:9]=[C:6]([CH2:7][O:19][C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([Br:12])[CH:14]=2)[CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 115633-BromophenolHCID 12078alpha-Chloro-m-nitrotoluene

生成物 1

HCID 283695411-Nitro-3-(3-bromo-phenoxymethyl)-benzene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 3-nitrobenzyl chloride (1.0 g, 5.83 mmol), 3-bromophenol (1.01 g, 5.83 mmol) and potassium carbonate (806 mg, 5.83 mmol) in acetone (25 mL) was heated to reflux for 23 hours. After cooling the solid was filtered off and the filtrate was concentrated under vacuum to a yellow residue which was dissolved in ethyl acetate (50 mL) and washed with 1N aqueous sodium hydroxide solution (25 mL) and water (25 mL) then dried and concentrated under vacuum to the title compound as a white solid (1.64 g, 91%).

後処理

  1. temperatureto reflux for 23 hours
  2. temperatureAfter cooling the solid
  3. filtrationwas filtered off
  4. concentrationthe filtrate was concentrated under vacuum to a yellow residue which
  5. dissolutionwas dissolved in ethyl acetate (50 mL)
  6. washwashed with 1N aqueous sodium hydroxide solution (25 mL) and water (25 mL)
  7. customthen dried
  8. concentrationconcentrated under vacuum to the title compound as a white solid (1.64 g, 91%)

出典と根拠

ORDレコード
ord-66b0cb8a4f3b4e9786205d036dcc245f
出典データセット
uspto-grants-2012_08
特許番号
US08236950B2

関連ノート

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