(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one → (S)-3-((S)-1-(5-chloro-6-methylpyridazin-3-yl)piperidin-3-yl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one

HRID 884371

反応式

HRID 884371 の反応式
[OH:1][C:2]([CH3:24])([CH3:23])[CH2:3][C@@:4]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]2[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]2)[CH2:6][CH2:5]1.[Cl:25][C:26]1[CH:31]=[C:30](Cl)[N:29]=[N:28][C:27]=1[CH3:33]>>[Cl:25][C:26]1[CH:31]=[C:30]([N:13]2[CH2:14][CH2:15][CH2:16][C@H:11]([N:7]3[CH2:6][CH2:5][C@:4]([CH2:3][C:2]([OH:1])([CH3:24])[CH3:23])([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[O:9][C:8]3=[O:10])[CH2:12]2)[N:29]=[N:28][C:27]=1[CH3:33]

参加物

3

反応物 2

HCID 58278645(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-oneHCID 587170494,6-Dichloro-3-methylpyridazine

生成物 1

HCID 58278656(S)-3-((S)-1-(5-chloro-6-methylpyridazin-3-yl)piperidin-3-yl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one

実験手順

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one and 4,6-dichloro-3-methylpyridazine following a procedure analogous to that described in Example 1. LC-MS Method 1 tR=1.37 min, m/z=459, 461(M+1).

出典と根拠

ORDレコード
ord-7a8639f7f84644d7859d067413fed446
出典データセット
uspto-grants-2012_08
特許番号
US08242111B2

関連ノート

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