HCID 11594031、化合物 → 2-(5-Hydroxy-pyridin-2-yl)-chromen-4-one

HRID 884705ノート

反応式

HRID 884705 の反応式
C[O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[C:16]([C:17](=[O:19])[CH:18]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:7][CH:8]=1>I.CC(O)=O.O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[O:10][C:11]3[C:16]([C:17](=[O:19])[CH:18]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:7][CH:8]=1

参加物

5

反応物 1

HCID 11594031HCID 11594031、化合物

生成物 1

HCID 116731392-(5-Hydroxy-pyridin-2-yl)-chromen-4-one収率 36.2%

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 962Water溶媒HCID 24841Hydrogen iodide溶媒

実験手順

2-(5-Methoxy-pyridin-2-yl)-chromen-4-one (790 mg, 3.12 mmol) in HI (10 mL) and AcOH (4 mL) was heated at reflux for 6 h. Reaction mixture was cooled to rt, diluted with water, neutralized and extracted with EtOAc to give crude product. This was purified by column chromatography using 5% MeOH in dichloromethane to give (270 mg, 36%) of 2-(5-Hydroxy-pyridin-2-yl)-chromen-4-one. MS (ES) m/z: 240.09 (M+1).

後処理

  1. temperatureat reflux for 6 h
  2. customReaction mixture
  3. extractionextracted with EtOAc
  4. customto give crude product
  5. customThis was purified by column chromatography

出典と根拠

ORDレコード
ord-216a17a503f24780aa4c399a64494fd6
出典データセット
uspto-grants-2012_08
特許番号
US08242130B2

反応ノート

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