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Phosphorus tribromide → [3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | [3-(4-Bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester | HCID 58237503 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | [3-(4-Bromo-2-bromomethyl-phenoxy)-phenyl]-acetic acid ethyl ester | HCID 58237602 | 75.3% |
反応手順
To [3-(4-bromo-2-hydroxymethyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.7 g, 1.86 mmol) in 1,4-dioxane (10 mL) was added phosphorus tribromide (0.19 mL, 2.04 mmol), and the reaction was stirred for 1 hour at room temperature. After work-up, 0.6 g of the desired product was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08242145B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-21b7adda40d34c2cbf5f59cf3b4a9824 |
| 出典メモ | uspto-grants-2012_08 |