Hydrochloric Acid → (2-Bromo-5-hydroxy-phenyl)-acetic acid methyl ester

HRID 885267ノート

反応式

HRID 885267 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=[O:11].Cl.[CH3:14]O>>[CH3:14][O:11][C:10](=[O:12])[CH2:9][C:3]1[CH:4]=[C:5]([OH:8])[CH:6]=[CH:7][C:2]=1[Br:1]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 572578212-(2-Bromo-5-hydroxyphenyl)acetic acid

生成物 1

HCID 58237580(2-Bromo-5-hydroxy-phenyl)-acetic acid methyl ester

反応条件

温度
70 °C

実験手順

To (2-bromo-5-hydroxy-phenyl)-acetic acid (1.5 g, 6.5 mmol) in MeOH (15 mL) was added HCl (4N in 1,4-dioxane; 3 mL), and the solution was heated to 70° C. for 8 hours. The mixture was concentrated to give the desired product as a white solid (1.2 g).

後処理

  1. concentrationThe mixture was concentrated

出典と根拠

ORDレコード
ord-ae8102e6250c4aa39cf8a1804d19e967
出典データセット
uspto-grants-2012_08
特許番号
US08242145B2

反応ノート

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