化工社化工社 化学情報印刷レポート · 研究参考用
Baclofen → 4-(4-Chlorophenyl)-2-pyrrolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Baclofen | HCID 2284 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(4-Chlorophenyl)-2-pyrrolidinone | HCID 185490 | — |
反応手順
To Baclofen (1.0 g, 4.7 mmol) in CH2Cl2 (20 mL) was added thionyl chloride (0.38 mL, 5.2 mmol), and the reaction was stirred for 10 minutes. Diisopropylethylamine (1.5 mL) was added, and the mixture was worked-up to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08242145B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-417fc5766c154604aeaddd8638a0c2ee |
| 出典メモ | uspto-grants-2012_08 |