Cyanogen Bromide → 1-ethyl-5-fluoro-1H-1,3-benzodiazol-2-amine

HRID 885451ノート

反応式

HRID 885451 の反応式
[CH2:1]([NH:3][C:4]1[C:5]([NH2:11])=[CH:6][C:7]([F:10])=[CH:8][CH:9]=1)[CH3:2].[N:12]#[C:13]Br.[NH4+].[OH-]>CO.O>[CH2:1]([N:3]1[C:4]2[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=2[N:11]=[C:13]1[NH2:12])[CH3:2]

参加物

6

反応物 3

HCID 10476Cyanogen BromideHCID 14923Ammonium HydroxideHCID 21286303N~1~-Ethyl-4-fluorobenzene-1,2-diamine

生成物 1

HCID 436615721-ethyl-5-fluoro-1H-1,3-benzodiazol-2-amine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of N1-ethyl-4-fluoro-benzene-1,2-diamine (1.54 g, 10.0 mmol) in MeOH (20 mL) and H2O (20 mL) was added cyanogen bromide (2.1 mL, 10.5 mmol, 5.0 M in acetonitrile). The resulting mixture was stirred at room temperature overnight. The resulting mixture was then adjusted to pH>9 with concentrated NH4OH and the resulting solid was collected by filtration, washed with H2O and hexanes to yield 1-ethyl-5-fluoro-1H-benzimidazol-2-ylamine MS 180 (M+1)+.

後処理

  1. filtrationthe resulting solid was collected by filtration
  2. washwashed with H2O and hexanes

出典と根拠

ORDレコード
ord-7eb9fcc163f946ba80e738d92200f61d
出典データセット
uspto-grants-2012_08
特許番号
US08242157B2

反応ノート

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