2,2-Difluoro-4-phenylbutan-1-ol → 2-(3-Bromophenyl)-2,2-difluoroethanol

反応式

C([O:3][C:4](=O)[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[CH:9]=1)([F:7])[F:6])C.FC(F)(CCC1C=CC=CC=1)CO>>[Br:14][C:10]1[CH:9]=[C:8]([C:5]([F:6])([F:7])[CH2:4][OH:3])[CH:13]=[CH:12][CH:11]=1

参加物

反応物 2

HCID 184257752,2-Difluoro-4-phenylbutan-1-ol

HCID 53419381Ethyl 2-(3-bromophenyl)-2,2-difluoroacetate

生成物 1

HCID 672463332-(3-Bromophenyl)-2,2-difluoroethanol

実験手順

Obtained from Intermediate 48 (21.1 g, 75.8 mmol) by the procedure described in Intermediate 2. The title compound was obtained (17.2 g, 96%) as oil.

出典と根拠

ORDレコード: ord-b5015aeb375948a7829e37f434b381c5
出典データセット: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08242177B2

反応ノート

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