2-(3-Bromophenyl)-2,2-difluoroethanol → 1-Bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene

HRID 885547ノート

反応式

HRID 885547 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([F:12])([F:11])[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]OCC(F)(F)CCC1C=CC=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:12])[CH2:9][O:10][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][Br:13])[CH:3]=1

参加物

3

反応物 2

HCID 672463332-(3-Bromophenyl)-2,2-difluoroethanolHCID 67246468{4-((6-Bromohexyl)oxy]-3,3-difluorobutyl}benzene

生成物 1

HCID 672452111-Bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene

実験手順

Obtained from Intermediate 49 (17.6 g, 74 mmol) by the procedure described in Intermediate 3. The crude oil was purified by distillation to yield the title compound as oil of 60% of purity (9.5 g). The distillation residue was purified by column chromatography with silica gel and methylene chloride as eluent to yield a second batch of 1-bromo-3-{2-[(6-bromohexyl)oxy]-1,1-difluoroethyl}benzene of 65% of purity (15.2 g) (overall yield: 53%).

後処理

  1. distillationThe crude oil was purified by distillation

出典と根拠

ORDレコード
ord-f30c18b5f0e9438ea101a29d20588bd2
出典データセット
uspto-grants-2012_08
特許番号
US08242177B2

反応ノート

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