Boc-L-3-Bromophenylalanine → 3-Bromo-L-phenylalanine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C@H:9]([NH:13]C(OC(C)(C)C)=O)[C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1>Cl.O1CCOCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[CH2:8][C@@H:9]([C:10]([OH:12])=[O:11])[NH2:13]参加物
4
実験手順
(2S)-3-(3-Bromophenyl)-2-(tert-butoxycarbonylamino)propionic acid (5.0 g, 14.5 mmol) was suspended in 4M HCl in 1,4-dioxane (75 mL) and stirred for 16 h at r.t. The white precipitate was filtered and washed with Et2O to give the title compound (3.2 g, 89%) as a white solid that required no further purification. δH (CDCl3) 8.32 (2H, s), 7.50-7.48 (2H, m), 7.34-7.29 (2H, m), 4.22 (1H, t, J 6.2 Hz), 3.13-3.11 (2H, m).
後処理
- filtrationThe white precipitate was filtered
- washwashed with Et2O
出典と根拠
- ORDレコード
- ord-858b8fa7a73b4dda9a90125618d922d2
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08242116B2
反応ノート
読み込み中…