5-chloro-1-isopropyl-1H-[1,2,4]triazole → 9-Bromo-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-2H-6-oxa-1,2-diaza-benzo[e]azulene

HRID 886065ノート

反応式

HRID 886065 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][CH2:13][CH2:12][C:11]3[C:7](=[N:8][NH:9][CH:10]=3)[C:6]=2[CH:15]=1.Cl[C:17]1[N:21]([CH:22]([CH3:24])[CH3:23])[N:20]=[CH:19][N:18]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][CH2:13][CH2:12][C:11]3[C:7](=[N:8][N:9]([C:17]4[N:21]([CH:22]([CH3:24])[CH3:23])[N:20]=[CH:19][N:18]=4)[CH:10]=3)[C:6]=2[CH:15]=1

参加物

3

反応物 2

HCID 541456465-chloro-1-isopropyl-1H-[1,2,4]triazoleHCID 178419296HCID 178419296、化合物

生成物 1

HCID 582044019-Bromo-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-2H-6-oxa-1,2-diaza-benzo[e]azulene収率 59%

実験手順

9-Bromo-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-2H-6-oxa-1,2-diaza-benzo[e]azulene was prepared from 9-bromo-4,5-dihydro-2H-6-oxa-1,2-diaza-benzo[e]azulene (450 mg, 1.7 mmol) and 5-chloro-1-isopropyl-1H-[1,2,4]triazole (369 mg, 2.55 mmol) to give 9-Bromo-2-(2-isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-2H-6-oxa-1,2-diaza-benzo[e]azulene as a white solid (375 mg, 59%). LCMS RT=5.05 min M+H+=374/376

出典と根拠

ORDレコード
ord-15d6a0f30dc948e8bcdf8b820a51a816
出典データセット
uspto-grants-2012_08
特許番号
US08242104B2

反応ノート

読み込み中…