Hydrochloric Acid → 2-(3-Bromophenyl)-2-hydroxypropanoic acid
反応式
C([O:3][C:4](=[O:15])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Br:14])[CH:9]=1)([OH:7])[CH3:6])C.[OH-].[K+].Cl>CO>[Br:14][C:10]1[CH:9]=[C:8]([C:5]([OH:7])([CH3:6])[C:4]([OH:15])=[O:3])[CH:13]=[CH:12][CH:11]=1参加物
5
実験手順
To a solution of 2-(3-Bromo-phenyl)-2-hydroxy-propionic acid ethyl ester (1.87 g, 6.7 mmol) in methanol (10 mL) was added potassium hydroxide (50% in water, 2 mL) and the solution was stirred at room temperature for 15 minutes. Hydrochloric acid (1 N) was added to adjust the pH to 4. The resulting mixture was extracted with ethyl acetate (10 ml×3). The combined organic layers were dried over sodium sulfate, filtered, and concentrated to afford the crude 2-(3-bromo-phenyl)-2-hydroxy-propionic acid as a white solid (1.6 g, 97%). MS: m/z 245 (M+H+).
後処理
- extractionThe resulting mixture was extracted with ethyl acetate (10 ml×3)
- dry with materialThe combined organic layers were dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5948dabbdce04dd2af46a5e89f622a8d
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08242280B2
反応ノート
読み込み中…