Vinyl butyrate → 2-(Trifluoromethyl)-1,2,3-propanetriol
反応式
[F:1][C:2]([F:10])([F:9])[C:3]([OH:8])([CH2:6][OH:7])[CH2:4][OH:5].[C:11]([O:16]C=C)(=O)[CH2:12][CH2:13][CH3:14]>>[F:1][C:2]([F:10])([F:9])[C:3]([OH:8])([CH2:6][OH:7])[CH2:4][OH:5].[C:11]([O:5][CH2:4][C:3]([CH2:6][O:7][C:11](=[O:16])[CH2:12][CH2:13][CH3:14])([OH:8])[C:2]([F:10])([F:9])[F:1])(=[O:16])[CH2:12][CH2:13][CH3:14]参加物
4
実験手順
In parallel reactions, a mixture of 2-(trifluoromethyl)-1,2,3-propanetriol (100 mg), Amano PS onto Sepabeads (100 mg), vinyl butyrate (0.3 ml) and solvent (as shown in table 1 below) (1 ml) was shaken at room temperature. The reactions were analysed by 19F NMR after 42 hours to give 2-(trifluoromethyl)-1,2,3-propanetriol (triol)/title compound/2-[(butanoyloxy)methyl]-3,3,3-trifluoro-2-hydroxypropyl butanoate (diester) peak ratios shown in table 1 below.