Ethanol → (S)-2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol

HRID 886707ノート

反応式

HRID 886707 の反応式
C([O:6][CH2:7][C@@:8]([OH:22])([CH2:13][NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:9]([F:12])([F:11])[F:10])(=O)CCC.C(O)C>Cl>[F:10][C:9]([F:11])([F:12])[C@@:8]([CH2:13][NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([OH:22])[CH2:7][OH:6]

参加物

4

反応物 2

HCID 702EthanolHCID 59487502Butanoic acid (S)-2-hydroxy-2-(trifluoromethyl)-3-(benzylamino)propyl ester

生成物 1

HCID 59487491(S)-2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol収率 104.1%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

(S)-3,3,3-Trifluoro-2-hydroxy-2-{[(phenylmethyl)amino]methyl}propyl butanoate (0.32 g) was dissolved in 5M hydrochloric acid (5 ml) and ethanol (5 ml) and heated at 100° C. for 3 hours. After cooling, the ethanol was evaporated and the remaining aqueous was basified with 2M sodium hydroxide and extracted with ethyl acetate (2 times). The combined organics were dried using a hydrophobic frit and evaporated to give the title compound as a pale yellow oil (0.26 g).

後処理

  1. temperatureAfter cooling
  2. customthe ethanol was evaporated
  3. extractionextracted with ethyl acetate (2 times)
  4. customThe combined organics were dried
  5. customevaporated

出典と根拠

ORDレコード
ord-ca916cdd642b4f43a25789870b31a6e0
出典データセット
uspto-grants-2012_08
特許番号
US08247377B2

反応ノート

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