4-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine → 2-(Methylsulfonyl)thieno[2,3-d]pyrimidine

HRID 886750

反応式

HRID 886750 の反応式
Cl[C:2]1[C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[N:7]=1>C(O)C>[CH3:11][S:8]([C:6]1[N:7]=[CH:2][C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=1)(=[O:9])=[O:10]

参加物

3

反応物 1

HCID 219883544-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine

生成物 1

HCID 219883562-(Methylsulfonyl)thieno[2,3-d]pyrimidine収率 85.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.

後処理

  1. customwas bubbled for 5 minutes
  2. additionTo this solution was added 10% palladium on activated charcoal (15 g)
  3. customTo the resulting mixture was bubbled hydrogen gas over night
  4. filtrationThe reaction mixture was filtered through Celite
  5. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-557104fe24e6488981a98533190e5ff9
出典データセット
uspto-grants-2012_08
特許番号
US08247409B2

関連ノート

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