Ethylamine → N-Ethyl-6-methyl-2-(methylsulfanyl)pyrimidin-4-amine
反応式
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.[CH2:11]([NH2:13])[CH3:12]>O>[CH2:11]([NH:13][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([S:9][CH3:10])[N:3]=1)[CH3:12]参加物
4
反応条件
- 温度
- 50 °C
実験手順
To the 4-chloro-6-methyl-2-(methylthio)pyrimidine from above was added 30 mL of a solution of 70% ethylamine in water. The reaction mixture was heated to 50° C. for 3 h. After completion, excess ethylamine was evaporated on rotary evaporator under vacuum. The solid was filtered and dried under vacuum to afford N-ethyl-6-methyl-2-(methylthio)pyrimidin-4-amine (20 g, 90% yield).
後処理
- customAfter completion, excess ethylamine was evaporated on rotary evaporator under vacuum
- filtrationThe solid was filtered
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-57504d35e3c04fd19a960d8fee9c70e8
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247408B2
反応ノート
読み込み中…