1,1-Dimethoxyethyl(dimethyl)amine → (E)-1-(dimethylamino)ethylidenethiourea
反応式
CO[C:3](OC)([N:5]([CH3:7])[CH3:6])[CH3:4].[NH2:10][C:11]([NH2:13])=[S:12]>C(Cl)Cl>[NH2:10][C:11](/[N:13]=[C:3](/[N:5]([CH3:7])[CH3:6])\[CH3:4])=[S:12]参加物
4
実験手順
N,N-Dimethyl acetamide dimethyl acetal (75 g, 0.56 mole) was added to a suspension of thiourea (33.0 g, 0.43 mole) in methylene chloride. The mixture was heated under reflux for 4 h. The solvent was removed and the residue was crystallized from 5% MeOH and diethyl ether affording (1E)-N′-(aminocarbonothioyl)-N,N-dimethylethanimidamide (47.8 g, 76% yield).
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 4 h
- customThe solvent was removed
- customthe residue was crystallized from 5% MeOH and diethyl ether
出典と根拠
- ORDレコード
- ord-6d1fefa295304ab58fd545239107a0d3
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247408B2
反応ノート
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