Hydrogen chloride-ethyl acetate → HCID 68578489、化合物
反応式
[N:1]1([C:6]2[CH:23]=[CH:22][C:9]3[CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][O:14][C:8]=3[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(OCC)(=O)C.[ClH:30]>>[ClH:30].[ClH:30].[N:1]1([C:6]2[CH:23]=[CH:22][C:9]3[CH2:10][NH:11][CH2:12][CH2:13][O:14][C:8]=3[CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
3
実験手順
A solution of tert-butyl 8-(pyrrolidin-1-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (110 mg, 0.345 mmol) in 4N hydrogen chloride-ethyl acetate (2 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (74.0 mg, 73.3%) as a solid.
後処理
- customthe solvent was evaporated under reduced pressure
- customThe residue was recrystallized from a mixed solvent of methanol and ether
出典と根拠
- ORDレコード
- ord-baee1012e92146398ed810ea4203af52
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247403B2
反応ノート
読み込み中…