Hydrogen chloride-ethyl acetate → HCID 68578005、化合物
反応式
[CH2:1]([N:3]([CH2:22][CH3:23])[C:4]1[CH:21]=[CH:20][C:7]2[CH2:8][N:9](C(OC(C)(C)C)=O)[CH2:10][CH2:11][O:12][C:6]=2[CH:5]=1)[CH3:2].C(OCC)(=O)C.[ClH:30]>>[ClH:30].[ClH:30].[CH2:22]([N:3]([CH2:1][CH3:2])[C:4]1[CH:21]=[CH:20][C:7]2[CH2:8][NH:9][CH2:10][CH2:11][O:12][C:6]=2[CH:5]=1)[CH3:23]参加物
3
実験手順
A solution of tert-butyl 8-(diethylamino)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (250 mg, 0.780 mmol) in 4N hydrogen chloride-ethyl acetate (6 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (144 mg, 62.9%) as a solid.
後処理
- customthe solvent was evaporated under reduced pressure
- customThe residue was recrystallized from a mixed solvent of methanol and ether
出典と根拠
- ORDレコード
- ord-e6bd917b94e44c24859fb7c3ba64308d
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247403B2
反応ノート
読み込み中…