Hydrogen chloride-ethyl acetate → 9-(2-Methyl-3-furyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride
反応式
[CH3:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7]1[C:17]2[O:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.C(OCC)(=O)C.[ClH:31]>C(OCC)(=O)C>[ClH:31].[CH3:1][C:2]1[O:3][CH:4]=[CH:5][C:6]=1[C:7]1[C:17]2[O:16][CH2:15][CH2:14][NH:13][CH2:12][C:11]=2[CH:10]=[CH:9][CH:8]=1参加物
4
実験手順
A mixture of tert-butyl 9-(2-methyl-3-furyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (300 mg, 0.911 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (3 ml) was stirred at room temperature for 0.5 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (230 mg, 95.0%) as a solid.