Hydrogen chloride-ethyl acetate → HCID 68579408、化合物
反応式
[CH3:1][CH:2]([C:4]1[C:14]2[O:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C:8]=2[CH:7]=[CH:6][CH:5]=1)[CH3:3].C(OCC)(=O)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH3:3][CH:2]([C:4]1[C:14]2[O:13][CH2:12][CH2:11][NH:10][CH2:9][C:8]=2[CH:7]=[CH:6][CH:5]=1)[CH3:1]参加物
4
実験手順
A mixture of tert-butyl 9-(1-methylethyl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (330 mg, 1.13 mmol), ethyl acetate (6 ml) and 4N hydrogen chloride-ethyl acetate solution (3 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (106 mg, 97.2%) as a solid.
後処理
- customthe solvent was evaporated under reduced pressure
- customThe residue was recrystallized from a mixed solvent of methanol and ether
出典と根拠
- ORDレコード
- ord-2798593318e8465e9a8fcb7fae3c274f
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247403B2
反応ノート
読み込み中…