Methylhydrazine → 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one
反応式
O[CH:2]1[O:6][C:5](=O)[CH:4]=[C:3]1[C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1.[CH3:16][NH:17][NH2:18]>C(O)C>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([C:3]2[CH:2]=[N:18][N:17]([CH3:16])[C:5](=[O:6])[CH:4]=2)=[CH:9][CH:10]=1参加物
4
反応条件
- 温度
- 85 °C
実験手順
A suspension of 5-hydroxy-4-(4-methoxyphenyl)-5H-furan-2-one (2.06 g, 10 mmol) in 30 mL of ethanol was stirred as methylhydrazine (0.78 mL, 1.5 eq) was added dropwise. The reaction was heated to reflux at 85° C. for 2 h, then the solvent was reduced at reduced pressure to give a solid, which was collected and washed with cold EtOH to give 1.0 g (46%) of 5-(4-methoxy-phenyl)-2-methyl-2H-pyridazin-3-one: MS m/z 217 (M+H).
後処理
- additionwas added dropwise
- temperatureThe reaction was heated
- customto give a solid, which
- customwas collected
- washwashed with cold EtOH
出典と根拠
- ORDレコード
- ord-15eafe635cdc44cab9f8b0694a3239b9
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247414B2
反応ノート
読み込み中…