2-Hydroxyquinoline → HCID 25142638、化合物

関与物質

反応手順

N-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxamide (35) (Scheme 6) was prepared from 3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-amine (34) and 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylic acid (22) according to the protocol described for the compound 23 (Scheme 4, Example 35). Colorless oil (0.1 g, 20%). 1H NMR (400 MHz, CDCl3): δ 1.67 (quintet, J=6.4 Hz, 2H); 1.73-1.78 (m, 2H); 2.62 (t, J=8.0 Hz, 2H); 2.70 (broad s, 4H); 3.05-3.08 (m, 5H); 3.47-3.49 (m, 2H); 3.85 (s, 3H); 4.21 (t, J=5.6 Hz, 2H); 6.86 (d, J=7.6 Hz, 1H); 6.92-6.95 (m, 2H); 6.98-7.03 (m, 1H); 7.35 (d, J=1.2 Hz, 1H); 7.52 (dd, J=6.0, 3.6 Hz, 1H); 7.70 (dd, J=6.0, 3.6 Hz, 1H). MS (ESI): m/z=404.5 (M+−H2O).

情報源と証拠