2,3-Dichlorobenzylamine → N-(2,3-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide

関与物質

役割	名称	HCID	仕込み量
反応物	2,3-Dichlorobenzylamine	HCID 587625	—
反応物	2-(Isoquinolin-5-YL)acetic acid	HCID 12018708	—
反応物	2-(Isoquinolin-5-yl)propanoic acid	HCID 22337638	—
生成物	N-(2,3-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide	HCID 9975707	—

反応手順

The title compound was prepared using the procedure described in Example 222B using 2,3-dichlorobenzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 359 (M+H)+; MS (ESI−) m/z 357 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.54 (d, J 7.1, 3H), 4.20 (m, 2H), 4.53 (q, J 7.1, 1H), 7.17 (d, J 7.8, 1H), 7.26 (t, J 7.8, 1H), 7.52 (d, J 8.1, 1H), 7.78 (t, J 7.8, 1H), 7.91 (d, J 6.5, 1H), 8.16 (d, J 8.1, 1H), 8.24 (d, J 6.4, 1H), 8.59 (d, J 6.2, 1H), 8.66 (t, J 5.8, 1H), 9.50 (s, 1H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08247413B2
出典データセット	uspto-grants-2012_08
ORD ID	ord-0de006628d8e424fbc9ab744bb52da89
出典メモ	uspto-grants-2012_08