関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | 4-Fluorobenzene-1,2-diamine | HCID 164584 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Fluorobenzimidazole | HCID 235698 | — |
反応手順
To the solution of 4-fluoro-benzene-1,2-diamine (10 g, 79.4 mmol) and triethylorthoformate (117 mL, 793 mmol) was added few drop of ethanol and the reaction mixture was refluxed at 150° C. overnight. The reaction mixture was concentrated and the residue was directly taken to the next step. [M+H]=137.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08247418B2 |
|---|
| 出典データセット | uspto-grants-2012_08 |
|---|
| ORD ID | ord-55385f5e23674ed5a2bf3443147fd061 |
|---|
| 出典メモ | uspto-grants-2012_08 |
|---|
