Methanol → Methyl 2-(2,4-dinitrophenyl)acetate

HRID 887595ノート

反応式

HRID 887595 の反応式
[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[CH2:13][C:14]([OH:16])=[O:15])([O-:3])=[O:2].OS(O)(=O)=O.[CH3:22]O>>[CH3:22][O:15][C:14](=[O:16])[CH2:13][C:5]1[CH:6]=[CH:7][C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 2215132,4-Dinitrophenylacetic acid

生成物 1

HCID 286146Methyl 2-(2,4-dinitrophenyl)acetate

実験手順

To a solution of (2,4-dinitro-phenyl)-acetic acid (5 g) in MeOH (100 mL) was added concentrated H2SO4 (1 mL) and the resulting solution was heated at reflux for overnight. After removing solvent in vacuum, the residue was partitioned between EtOAc and aqueous NaHCO3 (sat.). The organic solution was concentrated in vacuum to give the desired compound which was used without further purification.

後処理

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for overnight
  3. customAfter removing solvent in vacuum
  4. customthe residue was partitioned between EtOAc and aqueous NaHCO3 (sat.)
  5. concentrationThe organic solution was concentrated in vacuum

出典と根拠

ORDレコード
ord-b3e380bb17184136974608d232eb1e40
出典データセット
uspto-grants-2012_08
特許番号
US08247430B2

反応ノート

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