Triethylamine → N-(6-bromo-2-pyridinyl)-3-methylbut-2-enamide

HRID 887597

反応式

HRID 887597 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.CCN(CC)CC.[CH3:16][C:17]([CH3:22])=[CH:18][C:19](Cl)=[O:20]>C(Cl)Cl>[Br:8][C:4]1[N:3]=[C:2]([NH:1][C:19](=[O:20])[CH:18]=[C:17]([CH3:22])[CH3:16])[CH:7]=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 1023943-Methyl-2-butenoyl chlorideHCID 3008092-Amino-6-bromopyridine

生成物 1

HCID 43520526N-(6-bromo-2-pyridinyl)-3-methylbut-2-enamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-amino-6-bromopyridine (3.015 g, 0.017 mol) and Et3N (2.40 mL, 0.017 mol) in CH2Cl2 (20.0 mL), was added 3,3-dimethylacryloylchloride (1.96 mL, 0.017 mol) under N2 at 0° C. The mixture was slowly warmed to RT and stirred for 12 h. The reaction was quenched by the addition of H2O (20.0 mL), the organic layer was separated, dried over Na2SO4 and evaporated to dryness to yield crude compound which was used without purification.

後処理

  1. customThe reaction was quenched by the addition of H2O (20.0 mL)
  2. customthe organic layer was separated
  3. dry with materialdried over Na2SO4
  4. customevaporated to dryness
  5. customto yield crude compound which
  6. customwas used without purification

出典と根拠

ORDレコード
ord-075960414edf481099c04b6dcf2897ff
出典データセット
uspto-grants-2012_08
特許番号
US08247430B2

関連ノート

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