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Nitric Acid → 3-Acetylamino-6-bromo-2-nitro-benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | 5-Acetamido-2-bromobenzoic acid | HCID 2734159 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Acetylamino-6-bromo-2-nitro-benzoic acid | HCID 11403903 | 37% |
反応手順
5-(Acetylamino)-2-bromobenzoic acid (5.00 g, 19.4 mmol) was gradually added to fuming nitric acid (10 mL) at 0° C., and the mixture was stirred at room temperature for 4 hr. Water was added to the reaction solution, and the precipitated crystals were collected by filtration to give the title compound (2.19 g, yield 37%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08247429B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-b5474ff32d0c4ffd806e4e3938920c71 |
| 出典メモ | uspto-grants-2012_08 |