Butyrohydrazide → HCID 21914092、化合物

HRID 887931ノート

反応式

HRID 887931 の反応式
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13](=S)[NH2:14])(=[O:3])[CH3:2].[C:16]([NH:21][NH2:22])(=O)[CH2:17][CH2:18][CH3:19]>C(O)CCC>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]1[C:13]1[N:14]=[C:16]([CH2:17][CH2:18][CH3:19])[NH:21][N:22]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 77079ButyrohydrazideHCID 219141121-Acetyl-2,3-dihydro-1H-indole-2-carbothioamide

生成物 1

HCID 21914092HCID 21914092、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A suspension of intermediate (13) (0.0102 mole) in n-butanol (200 ml) was treated with butanoic acid hydrazide (0.0254 mole), stirred for 10 minutes, and then heated to reflux for 10 days. The reaction was cooled, concentrated in vacuo, distributed between DCM and distilled water. The concentrated organic phase was subjected to reverse phase preparatory column chromatography to give 1-acetyl-2,3-dihydro-2-(5-propyl-1H-1,2,4-triazol-3-yl)-1H-indole (compound 91).

後処理

  1. temperatureheated
  2. temperatureto reflux for 10 days
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated in vacuo
  5. distillationdistilled water

出典と根拠

ORDレコード
ord-1af4cf5e9c1e45a485af3af8555c6dd8
出典データセット
uspto-grants-2012_08
特許番号
US08247432B2

反応ノート

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