化工社化工社 化学情報印刷レポート · 研究参考用
4-Methylmorpholine → HCID 178501649、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Glycine methyl ester hydrochloride | HCID 122755 | — |
| 反応物 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 反応物 | HCID 178451416 | HCID 178451416 | — |
| 反応物 | HCID 178458058 | HCID 178458058 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178501649 | HCID 178501649 | 69.4% |
反応手順
1-Hydroxybenzotriazole hydrate (0.00036 mole), glycine methylester, hydrochloride (0.00047 mole), 4-methylmorpholine (0.00055 mole), and N′-(ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine monohydrochloride (0.00047 mole) were added to compound 117 (0.00036 mole) dissolved in DCM (30 ml) at 0° C. The mixture was allowed to warm to room temperature under nitrogen, and stirred overnight. The mixture was extracted with water, saturated NaHCO3, 2N citric acid, then saturated NaHCO3, dried, filtered, and concentrated, yielding 0.100 g (69%) of 1,1-dimethylethyl 2,3-dihydro-2-[4-[[(2-methoxy-2-oxoethyl)amino]carbonyl]-1H-imidazol-2-yl]-1H-indole-1-carboxylate (compound 118).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08247432B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-b658bee3c3c147aebd5bce6d7e7f4a21 |
| 出典メモ | uspto-grants-2012_08 |