化工社化工社 化学情報印刷レポート · 研究参考用
Methyl 4-Formylbenzoate → 4-[3-[1,3]-Dioxolan-2-yl-propenyl)benzoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-Formylbenzoate | HCID 15294 | — |
| 反応物 | [1-(1,3-Dioxan-2-yl)ethyl]triphenylphosphoniumbromide | HCID 22107466 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-[3-[1,3]-Dioxolan-2-yl-propenyl)benzoic acid methyl ester | HCID 86752164 | 50.3% |
反応手順
The olefin was prepared from 4.3 g (26.2 mmol) of the aldehyde 167, 13.94 g of [1-(1,3-dioxan-2-yl)ethyl]triphenylphosphoniumbromide and 12.6 mL (32.0 mmol) of n-BuLi in 75 mL of THF as described for the synthesis of 156 in Example 8. Flash chromatography (elution with 10% ethyl acetate in hexane) gave 3.27 g of the olefin 168. 1H NMR consistent with the product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723459 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-6120ae4e516c4335a3f2eb3671f18da1 |
| 出典メモ | uspto-grants-1998_03 |