n-(4-Tert-butylphenyl)-2-fluoronicotinamide → N-(4-tert-Butylphenyl)-2-[(1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]nicotinamide

HRID 888137ノート

反応式

HRID 888137 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2F)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[NH:23]1[C:27]2=[N:28][C:29]([CH2:32][NH2:33])=[CH:30][CH:31]=[C:26]2[CH:25]=[CH:24]1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2[NH:33][CH2:32][C:29]2[N:28]=[C:27]3[NH:23][CH:24]=[CH:25][C:26]3=[CH:31][CH:30]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 21959540n-(4-Tert-butylphenyl)-2-fluoronicotinamideHCID 692647382225154-13-0

生成物 1

HCID 16225622N-(4-tert-Butylphenyl)-2-[(1H-pyrrolo[2,3-b]pyridin-6-ylmethyl)amino]nicotinamide

実験手順

The titled compound was prepared from N-(4-tert-butyl-phenyl)-2-fluoro-nicotinamide and C-(1H-pyrrolo[2,3-b]pyridin-6-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 400 (M+H). Calc'd. for C24H25N5O—399.50.

出典と根拠

ORDレコード
ord-c1e9ef1c4f7d4b6082e9259a42115bf4
出典データセット
uspto-grants-2012_08
特許番号
US08247556B2

反応ノート

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