n-(4-Tert-butylphenyl)-2-fluoronicotinamide → N-(4-tert-Butylphenyl)-2-[(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)amino]nicotinamide
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2F)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[NH:23]1[C:27]2=[N:28][CH:29]=[CH:30][C:31]([CH2:32][NH2:33])=[C:26]2[CH2:25][CH2:24]1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2[NH:33][CH2:32][C:31]2[CH:30]=[CH:29][N:28]=[C:27]3[NH:23][CH2:24][CH2:25][C:26]=23)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]参加物
3
実験手順
The titled compound was prepared from N-(4-tert-butyl-phenyl)-2-fluoro-nicotinamide and C-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl)-methylamine dihydrochloride by the method described in Step A of Example 1. MS (ES+): 402 (M+H). Calc'd. for C24H27N5O—401.51.
出典と根拠
- ORDレコード
- ord-1bde5c2dc4454a0f83d4bd870fa97b20
- 出典データセット
- uspto-grants-2012_08
- DOI