戻る
化工社化工社 化学情報印刷レポート · 研究参考用
HRID 888197作成日：2026年10月26日

1-Chloro-4-(trifluoromethylsulfonyl)benzene → (3R)-3-methyl-1-{4-[(trifluoromethyl)sulfonyl]phenyl}piperazine

https://huagongshe.com/reaction/888197

反応式

関与物質

役割名称HCID仕込み量
反応物1-Chloro-4-(trifluoromethylsulfonyl)benzeneHCID 703324—
反応物(3R)-1-[4-(Methanesulfonyl)phenyl]-3-methylpiperazineHCID 26597658—
生成物(3R)-3-methyl-1-{4-[(trifluoromethyl)sulfonyl]phenyl}piperazineHCID 11580385—

反応手順

The title compound was prepared following the procedure of Intermediate 26, but starting from 1-chloro-4-(trifluoromethanesulfonyl)benzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a pale yellow solid. M+(ESI): 309.2. HPLC (Condition A), Rt: 2.3 min (HPLC purity: 99.5%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08247437B2
出典データセットuspto-grants-2012_08
ORD IDord-5485a5529022424594df9722d0f7b390
出典メモuspto-grants-2012_08