p-Bromochlorobenzene → (3R)-1-(4-chlorophenyl)-3-methylpiperazine

HRID 888200ノート

反応式

HRID 888200 の反応式
FC1C=CC([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:19][CH2:18][NH:17][C@H:16]([CH3:20])[CH2:15]3)=[CH:10][CH:9]=2)=CC=1.BrC1C=CC([Cl:28])=CC=1>>[Cl:28][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][NH:17][C@H:16]([CH3:20])[CH2:15]2)=[CH:10][CH:9]=1

参加物

3

反応物 2

HCID 7806p-BromochlorobenzeneHCID 58487952HCID 58487952、化合物

生成物 1

HCID 21071026(3R)-1-(4-chlorophenyl)-3-methylpiperazine

実験手順

The title compound was prepared following the procedure of Intermediate 22 but starting from 1-bromo-4-chlorobenzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a beige solid. M+(ESI): 211.2. HPLC purity: >96%).

後処理

  1. customThe title compound was prepared
  2. customPurification by flash chromatography (CHCl3/MeOH)

出典と根拠

ORDレコード
ord-c86ec60b08af4a9a965de98eed2e3c76
出典データセット
uspto-grants-2012_08
特許番号
US08247437B2

反応ノート

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