Hydrochloric Acid → HCID 68498763、化合物
反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:18]=[C:19]([CH:21]([OH:26])[C:22]([F:25])([F:24])[F:23])[CH:20]=2)[C:11]([O:13]C(C)(C)C)=[O:12])=[N:6][CH:7]=1.Cl>ClCCl>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([CH:18]=[C:19]([CH:21]([OH:26])[C:22]([F:25])([F:23])[F:24])[CH:20]=2)[C:11]([OH:13])=[O:12])=[N:6][CH:7]=1参加物
4
実験手順
To a solution of tert-butyl 3-(5-methylpyridin-2-yl)-5-(2,2,2-trifluoro-1-hydroxyethyl)benzoate (3.25 g, 8.85 mmol) in dichloromethane (15 mL) was added hydrogen chloride (4.0 M in dioxane; 11.1 mL, 44.2 mmol). The reaction mixture was stirred at ambient temperature. After 18 h, the mixture was concentrated. Dichloromethane was added the suspension was filtered. The solid cake was washed with dihchloromethane and dried under reduced pressure to give the hydrochloride salt of the title compound. MS 312.1 (M+1).