2,2,2-Trifluoroethyl Methanesulfonate → 2-Methyl-4-[2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-ylethynyl]-pyridine

反応式

[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.S(O[CH2:21][C:22]([F:25])([F:24])[F:23])(=O)(=O)C>>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[N:13]([CH2:21][C:22]([F:25])([F:24])[F:23])[CH:14]=2)[CH:5]=[CH:4][N:3]=1

参加物

反応物 2

HCID 5565652,2,2-Trifluoroethyl Methanesulfonate

HCID 178418884HCID 178418884、化合物

生成物 1

HCID 112659352-Methyl-4-[2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-ylethynyl]-pyridine

実験手順

The title compound, MS: m/e=280.1 (M+H+), was prepared in accordance with the general method of example 1 from 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine and 2,2,2-trifluoroethyl mesylate.

出典と根拠

ORDレコード: ord-08a2d881db674a16b9f53b7e318f89a5
出典データセット: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07091222B2

反応ノート

読み込み中…