(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester → (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

HRID 888509

反応式

HRID 888509 の反応式
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([O:16]CC2C=CC=CC=2)[CH:7]=1)[CH3:2]>CCO>[CH2:1]([O:3][C:4](=[O:24])[CH2:5][C:6]1[CH:11]=[C:10]([C:12]([F:14])([F:13])[F:15])[CH:9]=[C:8]([OH:16])[CH:7]=1)[CH3:2]

参加物

3

反応物 1

HCID 58148866(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

生成物 1

HCID 58149158(3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester (1.7 g, 5.6 mmol) was dissolved in EtOH (30 mL) and degassed with N2. 5% Palladium on carbon (1 g) was added, and the reaction was purged with H2 and then stirred under an H2 balloon at 50° C. overnight. The mixture was filtered and concentrated to give (3-Hydroxy-5-trifluoromethyl-phenyl)-acetic acid ethyl ester.

後処理

  1. customdegassed with N2
  2. addition5% Palladium on carbon (1 g) was added
  3. customthe reaction was purged with H2
  4. filtrationThe mixture was filtered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-624038e918754f518a3c72c43c9fda97
出典データセット
uspto-grants-2012_08
特許番号
US08247602B2

関連ノート

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