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N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide → 4-Methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide | HCID 14069348 | — |
| 反応物 | HCID 178418529 | HCID 178418529 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-one | HCID 46941396 | 77% |
反応手順
With the similar conditions of Example 29, steps (a) and (c), reaction of N-Methoxy-N-methyl-4-trifluoromethyl-benzamide, compound 31 a, with 3-methyl-1-butyl magnesium bromide, compound 29a, in THF gave the title compound in 77% yield; Calcd MW 244.26. Found MH+ 245.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08247610B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-42b29be0db1342bfaf79a46419c91ce7 |
| 出典メモ | uspto-grants-2012_08 |