1-Bromo-5-methanesulfonyl-2-methyl-3-nitro-benzene → 4-Bromo-6-methanesulfonyl-1H-indole

反応式

CN(C)[S:3]([C:6]1[CH:14]=[C:13]2[C:9]([CH:10]=[CH:11][NH:12]2)=[C:8]([Br:15])[CH:7]=1)(=[O:5])=[O:4].Br[C:18]1C=C(S(C)(=O)=O)C=C([N+]([O-])=O)C=1C>>[Br:15][C:8]1[CH:7]=[C:6]([S:3]([CH3:18])(=[O:5])=[O:4])[CH:14]=[C:13]2[C:9]=1[CH:10]=[CH:11][NH:12]2

参加物

反応物 2

HCID 591512721-Bromo-5-methanesulfonyl-2-methyl-3-nitro-benzene

HCID 591513424-bromo-1H-indole-6-sulfonic acid dimethylamide

生成物 1

HCID 591513054-Bromo-6-methanesulfonyl-1H-indole

実験手順

Prepared according to the method used in the preparation of 4-bromo-1H-indole-6-sulfonic acid dimethylamide using 1-bromo-5-methanesulfonyl-2-methyl-3-nitro-benzene in place of 3-bromo-4-N,N-trimethyl-5-nitro-benzenesulfonamide. The title compound was obtained as a white solid (1.8 g, 76%).

後処理

customPrepared

出典と根拠

ORDレコード: ord-b44f4ca4826d4285aa5e4aa9f854e4ab
出典データセット: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08252792B2

反応ノート

読み込み中…