Hydrochloric Acid → Tert-butyl Piperazine-1-carboxylate Hydrochloride

HRID 888923

反応式

HRID 888923 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[ClH:14]>ClCCl.CO>[ClH:14].[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 143452tert-Butyl piperazine-1-carboxylate

生成物 1

HCID 2755973Tert-butyl Piperazine-1-carboxylate Hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl-1-piperazinecarboxylate (15.0 g) in dichloromethane (150 mL) and methanol (150 ml) at 0° C. was added hydrogen chloride (40 mL; 2M solution in diethyl ether). The mixture was stirred at room temperature for 1.5 hours and reduced in vacuo to yield tert-butyl-1-piperazinecarboxylate hydrochloride (17.9 g).

出典と根拠

ORDレコード
ord-4b1883b735b44317934fd321f4c9a8ce
出典データセット
uspto-grants-2012_08
特許番号
US08252792B2

関連ノート

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