Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine--hydrogen chloride (1/1)
反応式
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][F:23])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[ClH:1].[F:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1参加物
5
実験手順
Add 4N HCl in 1,4-dioxane (86.096 mmoles, 21.524 mL) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (8.610 mmoles, 2.000 g) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate under reduced pressure to afford the title compound (8.679 mmoles, 1.780 g). MS (m/z): 133 (M+1).
後処理
- concentrationConcentrate under reduced pressure
出典と根拠
- ORDレコード
- ord-5543a4f165984544ae9b5d9454787701
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08252798B2
反応ノート
読み込み中…