Hydrochloric Acid → HCID 57988765、化合物
反応式
[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[N:10](COCC[Si](C)(C)C)[C:9]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][CH:28]4[CH2:30][CH:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:40])([F:39])[F:38])[CH:32]=4)[CH:26]=3)=[N:8][C:7]=2[N:6]([CH2:41][CH2:42][CH3:43])[C:5]1=[O:44])[CH2:2][CH3:3].Cl>C(O)C>[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[NH:10][C:9]([C:22]3[CH:23]=[N:24][N:25]([CH2:27][CH:28]4[CH2:30][CH:29]4[C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([C:37]([F:39])([F:38])[F:40])[CH:32]=4)[CH:26]=3)=[N:8][C:7]=2[N:6]([CH2:41][CH2:42][CH3:43])[C:5]1=[O:44])[CH2:2][CH3:3]参加物
4
反応条件
- 温度
- 85 °C
実験手順
A mixture of 1,3-dipropyl-8-{1-[2-(3-trifluoromethyl-phenyl)-cyclopropylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione (0.55 g, 0.087 mmol), 2 N HCl (2 ml), ethanol (3 ml) were heated at 85° C. for 3 hours. The mixture was cooled to 10-15° C. and solid material was separated. It was filtered off and washed with water (1 ml), diethyl ether (1 ml) to obtain the title compound (0.016 g, 37