Ethanol → (Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester

関与物質

反応手順

4-[1-Dimethylamino-eth-(Z)-ylidene]-2-methyl-4H-oxazol-5-one (36.4 g, 216 mmol) was dissolved in ethanol (300 ml) and sodium hydride (0.52 g, 0.022 mmol) was added at room temperature. The dark solution was refluxed for 1 h. The solvent was evaporated and the crude product [MS: m/e=215.5 (M+H+)] was used without any further purification for the next step.

情報源と証拠