Potassium Carbonate → HCID 15219197、化合物

HRID 889279ノート

反応式

HRID 889279 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N+:16]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[Sn]Cl.C([O-])([O-])=O.[K+].[K+]>CCO.Cl>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[NH2:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 24479Stannous ChlorideHCID 578349821-(Benzyloxy)-3-fluoro-2-nitrobenzene

生成物 1

HCID 15219197HCID 15219197、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

実験手順

To a solution of 1-benzyloxy-3-fluoro-2-nitrobenzene (10.0 g, 40.5 mmol) in 100 mL of EtOH and 50 mL of 1N HCl is added SnCl2 (38.3 g, 202.5 mmol) and the solution is refluxed for 2 h. After cooling the mixture to RT, it is adjusted to PH>7 with solid K2CO3 and extracted with EtOAc. The organic layer is washed with water and brine, and dried over sodium sulfate. The solvent is removed under reduced pressure to give the product as a yellow liquid.

後処理

  1. temperaturethe solution is refluxed for 2 h
  2. extractionextracted with EtOAc
  3. washThe organic layer is washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-011329f9824a435a98b6edc478f88614
出典データセット
uspto-grants-2012_08
特許番号
US08252820B2

反応ノート

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