関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 3-(Chloromethyl)-2-methylpyridine | HCID 12243711 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(2-Methylpyridin-3-yl)acetonitrile | HCID 19099286 | — |
反応手順
970 mg (6.85 mmol) of the compound from Example 37A are initially introduced into 10 ml DMF, 336 mg (6.85 mmol) sodium cyanide are added and the mixture is stirred overnight at 45° C. The reaction mixture is introduced on to 75 ml saturated ammonium chloride solution and extracted several times with methylene chloride. The combined organic phases are dried over sodium sulfate, filtered and concentrated. The residue is purified by means of flash chromatography on silica gel (mobile phase: methylene chloride/methanol 20:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08252817B2 |
|---|
| 出典データセット | uspto-grants-2012_08 |
|---|
| ORD ID | ord-3b8056ed72f54a7daab4e4e314dd8c78 |
|---|
| 出典メモ | uspto-grants-2012_08 |
|---|
